CREATE-C was a feasibility study to test a remote activity programme tailored for patients with colorectal cancer delivered completely at home and to investigate whether this intervention helps patients during treatment. We recruited patients from Cambridge University Hospitals NHS Foundation Trust who have been diagnosed with colorectal cancer (Stages II-IV) and prior to starting their 3-week chemotherapy treatment.
Physical activity and colorectal cancer recurrence
Evidence shows that physical activity is important in preventing recurrence of colorectal cancer. Being active can substantially reduce the risk of reoccurrence, by approximately 30%. However, there is limited research into the effect of being active from diagnosis through to the end of treatment. There are some large trials underway assessing the benefit of exercise prior to and immediately post-surgery, but currently there is less information of the benefit during treatment.
Being physically active and exercising has been shown to be safe and feasible post-surgery, during treatment and beyond. Guidelines suggest that patients should be encouraged to be as active as possible during this period. Being active during treatment may reduce fatigue, treatment side effects, help maintain muscle and reduce the risk of hospitalisations and infections during cancer treatment. However, as a result of the COVID-19 pandemic, face to face physical activity programmes for cancer patients in hospital and community settings have largely been suspended and patients may be concerned to attend programmes during this time. Some patients also prefer the option of tailored home-based programmes during their treatment.
This feasibility study was designed to test a remote activity programme tailored for patients with colorectal cancer, delivered completely at home. The programme built on the work of the established Cambridge University Hospital Trust’s Rehabilitation & Exercise during Addenbrooke’s Cancer Treatment (REACT) programme.
Starting in May 2021 we recruited patients from their outpatient oncology appointment prior to starting treatment.
Contact
CREATE-C.study@mrc-epid.cam.ac.uk
Investigators
Principal investigator
Dr Kirsten Rennie – University of Cambridge
Co-investigators
Dr Elizabeth Smyth – Cambridge University Hospitals NHS Foundation Trust
Nicola Day – Cambridge University Hospitals NHS Foundation Trust
Status
Completed.
Unit role
Unit led study with responsibility for data.
Sponsors
The study is jointly sponsored by CUHT and University of Cambridge
Funding
This work is supported by pump-prime funding from NIHR Cambridge Biomedical Research Centre and by the NIHR Cambridge Biomedical Research Centre Nutrition, Diet and Lifestyle research theme.
Data sharing
Please see our Data Sharing pages.
